Knee osteoarthritis
Conditions
Interventions
Observation group:Ultrasound guided small needle knife release combined with resistance movement. The above operation is performed once a week, with 4 weeks as one course of treatment.
Control group:Take 0.2 g/tablet of Celecoxib capsules orally, 1 tablet each time, once daily, for 4 consecutive weeks. Joint resistance exercise, 3 groups per day, for 4 consecutive weeks.
Sponsors
Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Meets the diagnostic criteria of traditional Chinese and Western medicine for knee osteoarthritis, belonging to the attack and remission stages; 2) Age range: 45-75 years old; 3) Patients with K-L staging of stages I, II, and III; 4) Patients with knee joint bone marrow edema under magnetic resonance imaging; 5) Sign the informed consent form and agree to join the patients in this study.
Exclusion criteria
Exclusion criteria: 1) Not meeting the diagnostic criteria for knee osteoarthritis; 2) K-L stage belongs to stage 0 or IV; 3) Uncontrolled joint infections, active joint tuberculosis, acute knee arthritis, rheumatoid arthritis, or local wounds; 4) Patients with meniscus or cruciate ligament injuries or other damages; 5) The affected limb has severe knee joint deformities, or is accompanied by severe vascular and neurological disorders or severe osteoporosis; 6) Have taken drugs that affect bone metabolism such as estrogen, steroid hormones, calcitonin, parathyroid hormone, bisphosphonates, fluoride, vitamin D, anticonvulsants, diuretics, etc. in the past 6 months; 7) Combined with severe primary type I diseases such as cardiovascular, cerebrovascular, and hematopoietic systems; 8) Combined with severe liver and kidney dysfunction; 9) Patients with mental illness or elderly dementia; 10) Allergic constitution, active period of gastrointestinal bleeding, ulcers, and perforation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vas; | — |
Secondary
| Measure | Time frame |
|---|---|
| EMG detection;Serum biochemical index detection;Western Ontario and McMaster Universities Arthritis Index;Traditional Chinese Medicine Efficacy Score;Ultrasound imaging indicators; | — |
Countries
China
Contacts
Public ContactZhijun Hu
Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed