psoriasis
Conditions
Interventions
Healthy subject group:No intervention
Oral Chinese medicine ointment formula group:Take the cream daily in the morning and evening for 12 weeks
Observation group:No intervention was done during this period, only follow-up.
Sponsors
Guang'anmen Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with psoriasis (1) Meet the diagnostic criteria for plaque psoriasis vulgaris; (2) 18 years old< age = 70 years old; (3) Standardized injection of secukinumab injection for more than 12 weeks, 4~8 weeks after the last injection, and the willingness to stop the drug; (4) PGA score =1, BSA =3%; (5) Signed informed consent and willing to accept follow-up. Inclusion Criteria for Healthy Subjects. Healthy control group: healthy subjects who will visit the China Academy of Chinese Medical Sciences from January 1, 2024 to November 1, 2026 The inclusion criteria are as follows: (1) 18 years old< age = 70 years old; (2) Persons with a physical examination (without a clear diagnosis of disease); (3) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with psoriasis (1) Pregnant, planning pregnancy and lactating women; (2) Systemic glucocorticoids, immunosuppressants, and retinoids within 4 weeks; (3) Patients with severe liver and kidney insufficiency; (4) Patients with severe mental illness; (5) Participated in other clinical trials in the past three months. Exclusion criteria for healthy subjects (1) Pregnant, planning pregnancy and lactating women; (2) Participated in other clinical trials in the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether psoriasis recurred within 48 weeks of enrollment.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical trait analysis;Genome-wide DNA methylation sequencing of peripheral blood mononuclear cells;Physician Global Assessment Score;BSA; | — |
Countries
China
Contacts
Public ContactCui Bingnan
Guang'anmen Hospital, China Academy of Chinese Medical Sciences
Outcome results
None listed