Pre-cancerous lesions of esophageal cancer
Conditions
Interventions
blank control group:Regular review of electronic endoscopy
intervention group:Taking Li Ge Di Huang Pills
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) low-grade intraepithelial neoplasia of esophageal squamous epithelium in the previous screening cohort of high incidence of esophageal cancer, and the pathologic diagnosis of low-grade intraepithelial neoplasia by endoscopic re-biopsy prior to enrollment; 2) the lesion measured =6mm under the endoscope at the time of endoscopic reexamination, and the scope of the lesion is still preserved after endoscopic bite examination (the diameter of the biopsy forceps operation was about 5mm, so to avoid the bias caused by biopsy operation) 3) Chinese medicine diagnosis meets the diagnostic criteria of Yin deficiency and dryness-heat syndrome; 4) Age =45 years and <75 years; 5) Able to understand the situation of this study, cooperate with regular endoscopic evaluation and follow-up, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) People with esophago-gastric fundus varices, esophageal stenosis; 2) People with history of esophageal or gastric surgery; 3) People with serious abnormalities of vital organ function; 4) People with contraindications to gastroscopy and mucosal biopsy; 5) People with a history of hypersensitivity or intolerance to the study drugs or components; 6) People with a diagnosis of esophageal/gastric cancer or other malignant tumors; 7) People with a life expectancy of less than 5 years for other serious illnesses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cancer rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| reversal rate;Symptomatic efficiency in TCM;Evaluation of the quality of life; | — |
Countries
China
Contacts
Public ContactYanni Lou
China-Japan Friendship Hospital
Outcome results
None listed