Alzheimer's disease
Conditions
Interventions
treatment group:Shenxiong Huanglian Jiedu granule
Sponsors
Wangjing Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) It conforms to the diagnostic standard of western medicine (refer to the core clinical standard of AD dementia formulated by NIA-AA in 2011) and the syndrome differentiation standard of traditional Chinese medicine; 2) Patients with mild to moderate AD: the total score of mini-mental state examination(MMSE) is 10-26; Clinical Dementia Rating(CDR) score is 1-2; 3) Age =60 years and =85 years; 4) The course of disease is =6 months; 5) The subjects can complete neuropsycholosgical test ; 6) The subjects have stable caregivers; 7) Patients and their legal guardians agree to participate in the experiment and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Dementia caused by other reasons, such as vascular dementia, Lewy body dementia, frontotemporal dementia, brain tumor, hydrocephalus, alcoholism, etc. 2) Patients with serious circulatory system, respiratory system, digestive system and other diseases; 3) Severe liver and kidney dysfunction; 4) Patients tak drugs that affect cognitive function except research drugs within one month; 5) Patients are allergic or known to be allergic to the drug ingredients in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's disease assessment scale-cog, ADAS-cog;mini-mental state examination, MMSE; | — |
Secondary
| Measure | Time frame |
|---|---|
| TNF-a;Aß1-42;T-tau;Activity of Daily Living Scale,ADL;IL-1ß;P-tau181;NfL;MDA;Clinical Dementia Rating,CDR;IL-6;TCM Syndrome Rating Scale;GSH-Px;Blood rheology;SOD; | — |
Countries
China
Contacts
Public ContactLiHao
Wangjing Hospital, China Academy of Chinese Medical Sciences
Outcome results
None listed