Sepsis
Conditions
Interventions
Control group:Conventional therapy for sepsis.
Treatment group:Based on the conventional therapy for sepsis, the Shenhuang Formula granules are added, to be taken once a day (one bag, containing 15g of ginseng and 7.5g of rhubarb), dissolved in 20
Sponsors
Capital Medical University Affiliated Beijing Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 96 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria for sepsis PICS: presence of infection, SOFA score = 2, and hospitalization for more than 14 days, and fulfillment of at least two of the following three indicators: C-reactive protein (CRP) > 2.0 mg/dL, albumin (Albumin, Alb) < 3.0 g/dL, lymphocytes < 800/µL. (2) Age = 18 years; (3) Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Pregnant or planning to become pregnant; (2) Severe mental illness; (3) Expected survival time of less than 28 days due to underlying diseases, such as uncontrolled malignant tumors or a heart attack within the past 30 days; (4) Vegetative state; (5) Diagnosed or highly suspected of having an acute infectious disease, such as active viral hepatitis or active tuberculosis; (6) Allergy to the active ingredient or excipients of the trial drug; (7) Participated in a clinical intervention trial within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 90-Day Mortality Rate;28-Day Mortality Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| TNF-a;BMI;Neutrophil Absolute Count;CD3+CD4;D-dimer;ß2-microglobulin;Immunoglobulin;C-Reactive Protein;Fibrin degradation products;IFN-?;ß-N-acetylglucosaminidase;Acute Gastrointestinal Injury Ranks;Mean arterial pressure;PBMC transcriptome sequencing;Direct bilirubin;Activated partial thromboplastin time;transferrin;Serum total bile acids;IL-1;1,3-ß-D-glucan;Lymphocyte Absolute Count;CD3+CD4+CD25;Serum Albumin;Blood urea nitrogen;triglyceride;Twelve-lead electrocardiogram;Glomerular filtration rate;SOFA score;Clinical Pulmonary Infection Score;Respiratory rate;IL-6;pH;Aspartate Aminotransferase;Creatine Kinase-Myocardial Band;Hemoglobin;Total bilirubin;TGF-ß;Treg;Arterial carbon dioxide partial pressure;Procalcitonin;Cardiac troponin I;Arterial oxygen partial pressure;Platelet count;APACHE ? score;Lactic acid;IL-4;Alanine Aminotransferase;N-terminal pro-brain natriuretic peptide;Serum pre-albumin;Blood pressure;IL-10;Prothrombin time;Galactomannan;Blood Creatinine;International normalized ratio; | — |
Countries
China
Contacts
Public ContactLiu Qingquan, Xu Xiaolong
Capital Medical University Affiliated Beijing Traditional Chinese Medicine Hospital
Outcome results
None listed