Knee Osteoarthritis
Conditions
Interventions
Group 1:Fuyuan Huoxue Tang+conventional anticoagulation+intervention with extramedullary localization osteotomy technology
Group 2:Intervention with conventional anticoagulation and extramedullary localization osteotomy technology
Group 4:Fuyuan Huoxue Tang+conventional anticoagulation+traditional intramedullary localization osteotomy intervention
Group 3:Intervention with conventional anticoagulation and traditional intramedullary localization osteotomy technology
Sponsors
Wangjing Hospital, Chinese Academy of Traditional Chinese Medicine, Huajiadi Street, Chaoyang District, Beijing
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) 50 years old = Enrollment age = 80 years old; (2) Those who meet KOA diagnosis and TKA surgical treatment indications; (3) No history of thrombosis related diseases within six months; (4) For first-time unilateral TKA without contraindications for implantation; (5) Color ultrasound examination of both lower limbs before surgery to exclude patients with thrombosis; (6) Able to cooperate in completing follow-up visits and have good compliance; (7) Voluntarily participate in this experiment and sign an informed consent form in writing.
Exclusion criteria
Exclusion criteria: (1) Those who do not meet the inclusion criteria; (2) Individuals with severe internal medicine underlying diseases, including heart and lung dysfunction, severe liver and kidney dysfunction, or bone marrow hematopoietic dysfunction; (3) Patients with abnormal coagulation function; (4) Individuals with allergic constitution or those who are allergic to the drugs involved in this experiment; (5) Patients with a history of gastrointestinal bleeding and a tendency to bleed; (6) Patients with severe mental illnesses; (7) Individuals who have participated in clinical trials of other investigational drugs or devices within the past three months; (8) Other researchers believe that it is not suitable for this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ultrasound examination of both lower limbs; | — |
Secondary
| Measure | Time frame |
|---|---|
| inflammatory cytokines;Lower limb circumference;visual analogue scale;coagulation index;hospital for special surgery knee score; | — |
Countries
China
Contacts
Public ContactMingjiang He
Wangjing Hospital of the Chinese Academy of Traditional Chinese Medicine
Outcome results
None listed