Rheumatoid Arthritis
Conditions
Interventions
Conventional therapy group:Methotrexate+Apremilast
Bushen Tongluo Decoction Group:Bushen Tongluo Decoction + Methotrexate+Apremilast
Sponsors
The Affiliated Hospital of Gansu Traditional Medicine University
Eligibility
Sex/Gender
All
Age
35 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Meets the aforementioned Western medical diagnosis, traditional Chinese disease classification, and syndrome diagnosis. (2) Age range between 35 and 60 years. (3) Classified with joint function levels I, II, or III, and hand X-ray staging falls under stages I, II, or III. (4) RA disease activity is mild to moderate. (5) Has not recently taken or been administered non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs (DMARDs), biologics, glucocorticoids, or similar medications intended to alleviate symptoms or improve rheumatoid arthritis condition.
Exclusion criteria
Exclusion criteria: (1) Patients who do not meet the diagnostic criteria. (2) Patients who have used glucocorticoid medications continuously for more than one month in the last six months (such as oral prednisone, methylprednisolone, or intravenous methylprednisolone). (3) Patients with concomitant other rheumatic diseases. (4) Patients who have taken medications in the past year that promote bone formation or absorption, such as calcium supplements, calcitriol, or teriparatide. (5) Patients with acute cardiovascular or cerebrovascular diseases. (6) Patients with significant concurrent systemic diseases, severe trauma, planned surgery, or severe infections. (7) Patients with a history of drug abuse, allergies to the medications used in this study, or a history of mental illness. (8) Women who are pregnant, breastfeeding, or in the preconception period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Pain Scale (VAS scale);TCM symptom score;adverse reaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute phase reactants;bone mineral density test;appraisal of life quality;imageological examination; | — |
Countries
China
Contacts
Public ContactGang Wang
The Affiliated Hospital of Gansu Traditional Medicine University
Outcome results
None listed