sepsis
Conditions
Interventions
Control Group(Western medicine conventional treatment plus Yiqi Huoxue placebo granule)):The conventional treatment of Western medicine plus placebo, which is based on the 2016 Sepsis 3.0 guidelines,
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Meet the definition and diagnostic criteria of sepsis 3.0: refer to the definition and diagnostic criteria of sepsis 3.0 jointly issued by the American Society of Critical Care Medicine (SCCM) and the European Society of Critical Care Medicine (ESICM) in 2016: there is a definite or suspected infection, and the SOFA score is = 2. (2) Meet the diagnostic criteria for pneumonia: community-acquired pneumonia: refer to the 2016 Guidelines for the Diagnosis and Treatment of Community-Acquired Pneumonia in Chinese Adults, hospital-acquired pneumonia: refer to the 2018 Guidelines for the Diagnosis and Treatment of Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia in Chinese Adults, and the source of sepsis infection is pneumonia; (3) invasive mechanical ventilation therapy; (4) Age = 65 years old and = 85 years old; Gender is not limited; (5) Those who signed informed consent
Exclusion criteria
Exclusion criteria: (1) Those who are in a dying state and may die within 24 hours; (2) Those with serious conditions requiring cardiopulmonary resuscitation; (3) Those with cachexia in advanced malignant tumors; (4) Those with acute coronary artery disease, such as acute myocardial infarction; (5) Those who are allergic to the taste of traditional Chinese medicine prescribed for Yiqi Huoxue granule, or those who are allergic to constitution; (6) pregnant or lactating women; (7) Those who have participated in other clinical trials in the past 3 months. (8) Other circumstances that the clinical investigator deems inappropriate to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Invasive mechanical ventilation duration; | — |
Secondary
| Measure | Time frame |
|---|---|
| CD14+/HLA-DR;Sepsis-related Organ Failure Assessment score;PD-L1;oxygenation index;7 day case fatality rate;Number of days in 28 days not requiring ventilator support; Length of stay in ICU;Hospitalization days;Quick Sepsis-related Organ Failure Assessment score;WBC (white blood cell);PD-1;APACHE? score; | — |
Countries
China
Contacts
Public ContactLi Jun
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine,
Outcome results
None listed