diminished ovarian reserve
Conditions
Interventions
acupuncture group:acupuncture
Sponsors
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) Meets the criteria for Group 3 and Group 4 of the POSEIDON POR classification criteria; (2) Female, 20 years = age < 40 years; (3) Regular menstruation (21-35 days); (4) Fertility needs, with a proposed IVF/ICSI-ET antagonist or microstimulation regimen to assist conception, and with a proposed transfer of 1-2 high-quality embryos at the cleavage stage or 1 blastocyst; (5) Voluntarily participate in the trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) FSH = 25 IU/L; (2) Diseases related to the reproductive physician's judgment that affect conception (any of the following may be excluded if they do not affect embryo transfer): congenital abnormalities in the development of reproductive organs, untreated endometrial polyps, untreated uterine adhesions, untreated uterine infections, untreated tubal hydrosalpinx, thin endometrium, uterine fibroids (>5 cm, submucosal uterine fibroids), endometriosis, or other organic diseases; (3) Repeated implantation failures (after at least 3 transfer cycles, fresh or frozen embryo transfer cycles involving the transfer of at least 4 high-quality embryos without pregnancy; or 2 consecutive fresh or frozen transfer cycles and the transfer of at least 4 cleavage-stage embryos or at least 2 high-quality blastocysts without obtaining a clinical pregnancy); (4) Combination of metabolic endocrine diseases such as uncorrected hyperprolactinemia, hyperandrogenemia, thyroid dysfunction, chronic hypoadrenocorticism, or other metabolic endocrine diseases; (5) Azoospermia in the male partner; (6) Those with combined serious cardiovascular, cerebrovascular, hepatic, renal, malignant tumor, hematopoietic system and mental diseases; (7) Those who have a history of acupuncture treatment; (8) Recurrent abortion (refers to 2 or more consecutive pregnancy losses with the same spouse that occurred before 28 weeks of gestation, including biochemical pregnancy); (9) Patients with severe anxiety, i.e., those with a score of >70 on the Self-Rating Anxiety Scale (SAS); (10) Chromosomal abnormalities and carriers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of follicles = 14mm on HCG day, E2 level on HCG day, endometrial thickness on HCG day, number of retrieved eggs, number of MII eggs, number of 2PN and 2PN fertilization rate, available embryo rate, high-quality embryo rate, embryo implantation rate, cycle cancellation rate, biochemical pregnancy rate, early pregnancy loss rate, sustained pregnancy rate, and live birth rate;antral follicular count (AFC), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), anti Mullerian hormone (AMH);Self-Rating Anxiety Scale; | — |
Countries
china
Contacts
Public Contactfangyigong
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences
Outcome results
None listed