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Based on PI3K/AKT/HIF-1 signaling pathway, to explore the clinical efficacy and mechanism of Zuoguiyin intervention in oxidative stress in the treatment of premature ovarian insufficiency

Based on PI3K/AKT/HIF-1 signaling pathway, to explore the clinical efficacy and mechanism of Zuoguiyin intervention in oxidative stress in the treatment of premature ovarian insufficiency

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2023000069
Enrollment
Unknown
Registered
2023-12-05
Start date
2024-01-01
Completion date
Unknown
Last updated
2023-12-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premature ovarian insufficiency

Interventions

Zuo GUI Yin group:Zuo GUI Yin oral Chinese medicine

Sponsors

Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
16 Years to 40 Years

Inclusion criteria

Inclusion criteria: (1) Meet the diagnostic criteria of premature ovarian insufficiency in accordance with the guidelines of the European Society of Human Reproduction and Embryology (ESHRE) and the Chinese Expert Consensus on the Clinical Diagnosis and Treatment of premature ovarian insufficiency in 2017; (2) meet the TCM syndrome standard of "kidney Yin deficiency"; (3) Those who are willing to sign informed consent and cooperate with research investigators. (4) Patients who have not used any hormone drug therapy in the past 3 months and have no contraindications to hormone therapy;

Exclusion criteria

Exclusion criteria: 1) Pregnancy, abnormal reproductive tract development, complete androgen insensitivity syndrome, Asherman Syndrome, polycystic ovary syndrome, thyroid disease, empty sella syndrome, central nervous system tumor, functional hypothalamic amenorrhea, ovarian resistance syndrome, etc. (2) diabetes or abnormal blood sugar; (3) Patients with heart, liver, spleen, lung, kidney, brain, blood, nervous, mental and other system diseases; (4) Poor scientific research compliance and incomplete data; (5) Patients who do not cooperate with the collection of physical type information.

Design outcomes

Primary

MeasureTime frame
TCM syndrome integral;

Secondary

MeasureTime frame
Six gonads;Menstrual score;Superoxide dismutase;catalase;AMH;Glutathione peroxidase;

Countries

China

Contacts

Public ContactHanlu

Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine

370201137@qq.com13999266599

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026