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The study on mechanism of denture stomatitis treated with Gan Lu Yin combined with fluconazole

The study on mechanism of denture stomatitis treated with Gan Lu Yin combined with fluconazole

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2022000100
Enrollment
Unknown
Registered
2022-06-28
Start date
2022-09-20
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Denture stomatitis

Interventions

Control Group:Western medicine
Experimental group:Chinese medicine compound western medicine

Sponsors

Xiyuan Hospital, Chinese Academy of traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. According to denture stomatitis, the TCM classification is Yin deficiency damp heat syndrome; 2. The general condition is acceptable, the mental state is good, the life can be taken care of by oneself, and the patient has not been diagnosed with mucosal disease in the past; 3. Patients with upper partial denture or total denture for 6 months or more, aged 50-85 years old; 4. Patients with dentures had symptoms such as mucous membrane redness, bad breath, dry mouth, pain, oral bleeding, angular stomatitis, glossitis, and decreased taste; 5. Candida positive in laboratory culture.

Exclusion criteria

Exclusion criteria: 1. Patients with systemic diseases such as HIV, systemic mycosis, liver and kidney dysfunction; 2. Antibiotics, antifungal drugs, immunosuppressants or oral corticosteroids were used 1 month before repair; 3. Oral, maxillofacial and adjacent organ mass and inflammation, salivary gland and duct diseases; 4. Dry mouth syndrome and non Candida mucosal diseases; 5. Wearing bad prostheses that cause obvious trauma or affect oral hygiene in recent 1 month; 6. Those who do not accept traditional Chinese medicine treatment and allergic constitution; 7. Patients who are allergic to fluconazole and its inactive ingredients or other azole drugs; 8. Patients taking terfenadine, cisapride, asmizole, pimozide, quinidine and erythromycin.

Design outcomes

Primary

MeasureTime frame
The stool is dry and knotted;Pulse count;Throat dryness;The gums are congested;Candida albicans;Mycological examination;Less fur;Piss yellow;The size of the mucosal plaque;Jaded;Red Tongue;

Secondary

MeasureTime frame
Dry Mouth;Swollen and painful gums;Degree of mucosal congestion;Local lesions, burning pain;

Countries

China

Contacts

Public ContactGaoweinuo
764953180@qq.com13810505896

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026