Degenerative lumbar spinal stenosis
Conditions
Interventions
none:none
Sponsors
Medical Experimental Center of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet the above diagnostic criteria and are clearly diagnosed as degenerative lumbar spinal stenosis, and those whose lumbar spine MRI showed thickening of the ligamentum flavum of the responsible segment >4mm were included in the experimental group. 2. Patients with burst fracture or lumbar spine trauma and no obvious lumbar degenerative disease on lumbar spine MRI were included. 3. Patients who are ineffective after conservative treatment for more than 3 months and have clear surgical indications must be routinely excluded from surgical treatment. 4. Age 40 to 75 years old. 5. Patients who participated voluntarily and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Under the age of 40 or over 75, pregnant or breastfeeding women, patients with other spinal diseases such as ankylosing spondylitis, vertebral compression fractures and tumors. 2. Patients with definite lumbar spondylolisthesis of grade II or higher; patients who plan to undergo revision surgery with lumbar internal fixation. 3. Accompanied by ossification of the ligamentum flavum. 4. Combined with diabetes and other diseases that have a potential impact on the ligamentum flavum. 5. Special populations who are not suitable to participate in clinical research (blind, deaf, mute, intellectual or mental disorders, etc. who cannot cooperate with them). 6. Patients with serious primary diseases such as heart, brain, liver, kidney, hematopoietic system or other contraindications to surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biochemical tests;histopathology;Videography;Proteomics;Transcriptomics; | — |
Countries
China
Contacts
Public ContactZhang Ping
Wangjing Hospital of China Academy of Chinese Medical Sciences
Outcome results
None listed