Brain effect of percutaneous auricular stimulation on patients with consciousness disorder and its multimodal imaging mechanism

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ITMCTR

Registry ID

ITMCTR2022000091

Enrollment

Unknown

Registered

2022-06-21

Start date

2022-09-20

Completion date

Unknown

Last updated

2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Consciousness disorder subjects

Interventions

transcutaneous electrical stimulation of auricular acupuncture points:transcutaneous electrical stimulation of auricular acupuncture points on vagus nerve

transcutaneous electrical stimulation of auricular acupuncture points out of vagus nerve:transcutaneous electrical stimulation of auricular acupuncture points out of vagus nerve

normal control:no intervention

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: ? The multi Society Task Force on vs/uws. n Engl J Med 1994, giacino JT, et al. neurology.2000. ? Age 18-50 years old, regardless of gender. ? More than 12 weeks after sudden disturbance of consciousness, i.e. sleep wake cycle occurs, and eyes open coma occurs for more than 12 weeks). ? Doc caused by focal injury (craniocerebral trauma and stroke) with intact brain structure.

Exclusion criteria

Exclusion criteria: ? History of epilepsy. ? Doc caused by hypoxic ischemic encephalopathy and other whole brain factors. ?There are contraindications to MR scanning.

Design outcomes

Primary

Measure	Time frame
CRS-R;	—

Secondary

Measure	Time frame
Electro-encephalogram (EEG), ERP;fMRI;	—

Countries

China

Contacts

Public ContactJinling Zhang/Peijing Rong

jinlingzhang407@sina.com64089407

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026