A randomized controlled clinical study on the treatment of mild to moderate knee osteoarthritis with traditional Chinese medicine ointment rubbing

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ITMCTR

Registry ID

ITMCTR2022000081

Enrollment

Unknown

Registered

2022-06-25

Start date

2022-09-01

Completion date

Unknown

Last updated

2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis

Interventions

Observation group:Chinese herbal ointment rubbing

control group:Diclofenac diethylamine emulsion for external wiping of knee joint

Eligibility

Sex/Gender

All

Age

30 Years to 100 Years

Inclusion criteria

Inclusion criteria: (1) Meet the diagnostic criteria (refer to the diagnostic criteria of the guidelines for the diagnosis and treatment of osteoarthritis (2018 Edition) issued by the branch of orthopaedics of the Chinese Medical Association). ? Repeated knee pain in the past month; ? X-ray films (standing position or weight-bearing position) showed narrowing of joint space, subchondral bone sclerosis and / or cystic change, and osteophyte formation at the joint edge; ? Age = 50 years old; ? Morning stiffness time = 30min; ? There is bone fricative sound (sensation) during activity. It can be diagnosed if any 2 of ? and ? ? ? ? are met.); (2) Age 30 and above; (3) Western Ontario and McMaster University Osteoarthritis Index (WOMAC) = 48 points; (4) Kellgren Lawrence (K-L) is classified as grade I, II or III; (5) Fluent in speech, clear in mind, can accurately evaluate and describe their own discomfort symptoms; (6) Sign informed consent.

Exclusion criteria

Exclusion criteria: (1) The patient had a history of knee replacement; (2) The patient had a history of rheumatoid arthritis and bone tumor; (3) The patient has ligament injury or rupture; (4) Previous allergic history of Chinese herbal medicine (5) anti inflammatory and analgesic drugs were used within 1 week before enrollment; (6) The local knee joint was treated with topical drugs within 1 week before enrollment (7) the knee joint was treated with drug injection within 1 month before enrollment.

Design outcomes

Primary

Measure	Time frame
Visual analog scale;	—

Secondary

Measure	Time frame
Knee injury and osteoarthritis outcome score;Thigh circumference;Western Ontario and McMaster Universities Osteoarthritis Index;	—

Countries

China

Contacts

Public ContactZhang Xin

Wuzhai County Hospital of traditional Chinese medicine

xiaoxiangbobo@126.com17610415056

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026