hyperuricemia, Metabolic syndrome, Gout
Conditions
Interventions
Metabolic syndrome with gout:none
Metabolic syndrome with hyperuricemia:none
Metabolic syndrome with uric acid nephropathy:none
Sponsors
Guang'anmen Hospital, Chinese Academy of traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Healthy people: (1) no previous history of diabetes, no hypoglycemic drugs taken or injected, fasting blood glucose < 6.1mmol/l, 2h postprandial blood glucose < 7.8mmol/l. (2) No previous history of hypertension, no antihypertensive drugs, and random blood pressure < 130/85mmhg. (3) No history of hyperlipidemia, no lipid-lowering drugs, fasting TG < 1.7mmol/l, fasting HDL-C = 1.04mmol/l; (4) There was no history of hyperuricemia or gout and family history in the past, and had not taken any drugs to reduce uric acid. At the same time, fasting blood uric acid was < 420umol/l in men and < 360umol/l in women; Metabolic syndrome: (1) abdominal obesity: Chinese male waist = 90cm, female waist = 85CM; (2) Hyperglycemia: fasting blood glucose = 6.1mmol/l or blood glucose = 7.8mmol/l 2h after glucose load and / or diabetes has been diagnosed and treated; (3) Hypertension: blood pressure = 130/85mmhg and (or) has been confirmed as hypertension and treated; (4) Fasting TG = 1.7mmol/l; (5) Fasting hdl-c<1.04mmol/l; It is sufficient to comply with any three or more of (1) - (5). Asymptomatic hyperuricemia: fasting serum uric acid = 420 umol/l in males and = 360 umol/l in females; Patients with hyperuricemia caused by other reasons were excluded. Gout: refer to the gout classification standard jointly proposed by ACR and EULAR in 2015. If the score is = 8, it can be diagnosed. Gouty nephropathy: patients who have a history of hyperuricemia and exclude secondary hyperuricemia caused by other kidney diseases, blood diseases, tumor radiotherapy, chemotherapy or thiazide diuretics, and have one or more of the following clinical conditions: ? persistent abnormal urine, ? renal function damage, ? uric acid kidney stones, whose renal damage can exclude other causes.
Exclusion criteria
Exclusion criteria: (1) Patients with moderate to severe cognitive understanding or visual impairment who cannot cooperate to complete treatment and examination; (2) Patients with severe heart, lung, liver, kidney and other important organs and blood system dysfunction; (3) Various infections, acute metabolic disorders, diabetes foot and other serious complications of diabetes; (4) Pregnant or lactating women; (5) Previous or current cancer history or other fatal diseases that may affect short-term survival; (6) Patients participating in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood uric acid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Urea nitrogen;Postprandial blood glucose;Blood creatinine;Urea nitrogen;Low density lipoprotein;cholesterol;triglyceride;High density lipoprotein;Fasting blood glucose;glycosylated hemoglobin; | — |
Countries
China
Contacts
Public Contactchenliang
Guang'anmen Hospital, Chinese Academy of traditional Chinese Medicine
Outcome results
None listed