ICU acquired muscle weakness
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years old; 2. ICU stay over 24h; 3. In line with ICUAW clinical diagnostic criteria; 4. Acute physiology and chronic health status score (APACHEII) 8 ~ 20 points; 5. Hemodynamics is relatively stable; 6. Mechanical ventilation, oxygen concentration (FiO2) < 0.6, PEEP < 10cmH2O 7. Patients and their families voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: 1. with primary neurological and muscular diseases before admission, including brain and spinal cord injury, Guillain-Barre syndrome, myasthenia gravis, etc.; 2. Limb disability, limb instability fracture; 3. Malignant tumor; 4. with active bleeding; 5. The ICU stay time will be less than 24h; 6. Those who have a history of drug addiction or alcoholism and cannot stop during the experiment; 7. An irreversible disease; 8. Due to difficulties to tolerate treatment intervention scheme, give up treatment of patients; 9. Family members or myself refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MBI;Quadriceps femoris muscle area, thickness;subcutaneous tissue thickness;medical research council, MRC;ultrasonic intensity of rectus femoris;vastus intermediate muscle thickness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mechanical ventilation;the 28-day survival rate;the rate of detachment at the second week; | — |
Countries
China
Contacts
Shanghai Genernal Hospital