Chronic cyclosporine nephropathy
Conditions
Interventions
Control group:Conventional treatment
therapy group:Conventional treatment+traditional Chinese medicine
The AA control group:none
Sponsors
The First Affiliated Hospital of ZheJiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for aplastic anemia; 2. Meet the diagnostic criteria of chronic cyclosporin A nephropathy; 3. Meet the diagnostic criteria of TCM syndromes; 4. Patients are between 18-75 years old; 5. Aplastic anemia, infection, acidosis, electrolyte disturbance, high blood pressure, etc. are well controlled; 6. No other organ failure.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic or allergic to the known ingredients of the study drug; 2. Patients diagnosed with acute kidney injury, and patients undergoing hemodialysis and peritoneal dialysis; 3. Patients with severe damage to heart, liver, lungs and other organs, or patients with malignant tumors, active tuberculosis and other wasting diseases; 4. Those with gastrointestinal bleeding, or those who need to take other types of Chinese medicine during the test period; 5. Those who do not cooperate with treatment; 6. Those with recent history of surgery; 7. Pregnant and lactating women; 8. Researchers believe that it is inappropriate to participate in clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LC3-II;SOD;Beclin-1;Ang(1-7);ACE;p62;MDA;Klotho;TGF- beta 1;Ang II;Serum creatinine;ACE2; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood urea nitrogen;CysC;Uric acid;ACR; | — |
Countries
China
Contacts
Public ContactKeDa Lu
The First Affiliated Hospital of ZheJiang Chinese Medical University
Outcome results
None listed