Panic Disorder
Conditions
Interventions
Citalopram combined with acupuncture group(after citalopram treatment failed):Citalopram combined with acupuncture
Acupuncture combined with CBT treatment group (after acupuncture treatment failed):Acupuncture and moxibustion combined with CBT
Citalopram treatment group:Citalopram treatment
Healthy control group:No intervention
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: For patients: 1. Patients with panic disorder who meet the diagnostic criteria for panic disorder (M.I.N.I diagnosis) of the American Mental Disorders Diagnosis and Statistics Manual(DSM)-Fourth edition; 2. Aged 18-60 years; 3. PDSS total score is more than 7 and HAMD- 17 total score is less than 18; 4. Education above Junior middle school level; 5. Sign the informed consent; 6. Right-handed. For healthy controls: 1. Aged 18 to 60 years, right-handed, junior high school education or above; 2. Match with PD patient group in terms of gender, age, dexterity and education; 3. PDSS total score is less than 6 and HAMD- 17 total score is less than 7; 4. Signed the informed consent.
Exclusion criteria
Exclusion criteria: For patient: 1. According to the judgment of the researcher, the patient is at risk of self-injury, suicide or injury to others, or is at moderate risk of suicide as assessed by the MINI diagnosis; 2. Patients with organic brain diseases, major physical diseases and infectious diseases; 3. Consistent with the diagnosis of schizophrenia, bipolar disorder, depression, other anxiety disorders and other mental disorders; 4. Evidence of drug dependence and psychoactive substance use; 5. Patients who took SSRIs within 4 weeks before enrollment or received treatment with systemic effects on brain function; 6. Pregnant and lactating women; 7. Allergic to alcohol skin disinfection; 8. Fear of acupuncture and acupuncture, needle fainting patients; 9. Other conditions that the researcher considers inappropriate for inclusion; (Add the following exclusion criteria in patients with resting state MRI:Patients with metal implants and metal dentures in the body and MRI taboos such as claustrophobia.) For healthy controls: 1. Those who have metal implants and metal dentures in their bodies, are pregnant or breastfeeding, and have MRI contraindications such as claustrophobia; 2. No serious physical disease; 3. No history of mental illness that meets the diagnostic criteria, no family history of mental illness; 4. Those who have received systematic treatment that affects brain function within 4 weeks before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PDSS; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMD;Chinese Traditional medicineSyndrome Observation Scale;PDQ-4+;PASS; | — |
Countries
China
Contacts
Public ContactLi Zhangjiang
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed