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Difference of PTEN / PI3K / Akt signaling pathway between colorectal damp heat syndrome and spleen stomach weakness syndrome in patients with colon adenoma

Difference of PTEN / PI3K / Akt signaling pathway between colorectal damp heat syndrome and spleen stomach weakness syndrome in patients with colon adenoma

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2000004106
Enrollment
Unknown
Registered
2020-09-23
Start date
2020-10-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adenoma of colon

Interventions

Sponsors

Shanghai Traditional Chinese MedicineIntegrated Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. according to the diagnosis of colon adenoma: according to the jnet classification of 2A under endoscopy, the pathological diagnosis was in accordance with low-grade intraepithelial neoplasia of adenoma; 2. TCM syndrome differentiation was consistent with large intestine damp heat syndrome or spleen and stomach weakness syndrome; 3. aged 18-75 years old; 4. signed informed consent and voluntarily entered the trial. Large intestine dampness heat syndrome: main symptoms: (1) stool frequency increased, diarrhea is more smelly, or pus blood, or such as water injection; (2) there are urgent afterweight, anus burning; (3) red tongue, yellow or yellow greasy or yellow dry. Secondary symptoms: (1) abdominal pain refused to press, fullness and discomfort; (2) Fanke drink or do not want to drink; (3) constipation or loose stool; (4) hot and sweating; (5) short red urine; (6) head and body weight; (7) pulse slip number. Syndrome determination: 2 main symptoms + 3 secondary symptoms, Spleen and stomach deficiency syndrome: main symptoms: (1) abdominal distension, less intake, after eating, bloating; (2) loose and thin stool; (3) mental fatigue and fatigue; (4) shortness of breath and lazy speech; (5) light tongue, thin and white fur. Secondary symptoms: (1) continuous abdominal pain, from time to time, like warming and pressing; (2) cold shape and cold limbs; (3) no Chinese complexion; (4) poor appetite; (5) loose stool; (6) fat tongue; (7) fine pulse. Syndrome determination: 2 main symptoms + 3 secondary symptoms

Exclusion criteria

Exclusion criteria: (1) patients under 18 years old or over 75 years old, pregnant and lactating women; (2) pathological diagnosis of non adenomatous low-grade intraepithelial neoplasia; (3) colonoscopy contraindications or other reasons can not be performed colonoscopy; (4) enteroscopy diagnosis of enteritis, intestinal ulcer, non intestinal polyps; (5) digestive tract tumors; (6) Combined with cardiovascular and cerebrovascular, liver and kidney, blood system and other serious primary diseases, mental patients; (7) syndrome differentiation of traditional Chinese medicine has concurrent syndrome.

Design outcomes

Primary

MeasureTime frame
AKT Protein;PTEN Protein;PI3K Protein;

Countries

China

Contacts

Public ContactDai Yancheng

Shanghai Traditional Chinese MedicineIntegrated Hospital

daiyancheng2005@163.com+86 13795294873

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026