acute ischemic stroke
Conditions
Interventions
Control group:Normal saline
Sponsors
Dongfang Hospital Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years old; 2. Clinical diagnosis of acute ischemic stroke, the clinical symptoms or signs are considered to be caused by intracranial and extracranial large artery occlusion. Hospitals with conditions recommend non-invasive imaging examination to confirm the diagnosis of the responsible large vessel occlusion; 3. Neurological deficit score (NIHSS) >=6 points; ASPECT score >=6 points; 4. The time from the onset of the anterior circulation to the completion of femoral artery puncture is within 6 hours. If there is an obvious ischemic penumbra, the thrombus removal time window can be extended to 6~24 hours according to the patient's condition; 5. It is reasonable to perform post-circulation mechanical thrombectomy therapy; 6. CT or MR examination to rule out intracranial hemorrhage and large-scale cerebral infarction. A large area cerebral infarction in the anterior circulation is defined as CT or DW imaging, ASPECTST score =70ml, or infarct volume >1/3 of the middle cerebral artery blood supply area; a large area cerebral infarction in the posterior circulation is defined as infarct volume> 1/3 brainstem volume.
Exclusion criteria
Exclusion criteria: 1. Hemorrhagic constitution or receiving anticoagulation treatment, including coagulation factor deficiency disease, international normalized ratio (INR)>1.7; 2. Active bleeding or major surgery in the past 2 weeks, significant trauma or bleeding disease; 3. The modified Rankini scale score (mRs) of the patients before the stroke occurred>3; 4. Seriously allergic to contrast agents; 5. Refractory hypertension that cannot be controlled by drugs (continuous systolic blood pressure >=185mmg, or continuous diastolic blood pressure >=110mmHg); 6. Blood sugar 22.0mimo/L; 7. The platelet count is less than 100x19/L; 8. Serious heart, liver and kidney function abnormalities; 9. Pregnancy; 10. Suspected infectious emboli, such as septic emboli or bacterial endocarditis; 11. End-stage disease leads to life expectancy of patients <3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NIHSS score; | — |
Countries
China
Contacts
Public ContactLe Wang
Beijing University of Chinese Medicine
Outcome results
None listed