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Study on the LTP-Like and LTD-Like plasticity of human motor cortex by Paired Associative Electroacupuncture and Transcranial Magnetic Stimulation

Study on the LTP-Like and LTD-Like plasticity of human motor cortex by Paired Associative Electroacupuncture and Transcranial Magnetic Stimulation

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2000004066
Enrollment
Unknown
Registered
2020-11-20
Start date
2020-11-18
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Sponsors

Guangdong Provincail Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: (1) Healthy subjects aged between 18 and 50 years; (2) Right-handedness, regardless of gender; (3) No previous neurological, mental or motor system diseases; (4) Did not receive any peripheral stimulation (such as acupuncture, peripheral electrical stimulation, etc.) and central stimulation (such as rTMS, tDCS, etc.) within the last 3 months; (5) Willing to accept electroacupuncture and never had history of needle fainting; (6) Those who voluntarily participate in this study and sign the informed consent.

Exclusion criteria

Exclusion criteria: (1) Patients with mental system disorders, such as schizophrenia, anxiety disorders, personality disorders, etc.; (2) Patients with nervous system disorders, such as brain trauma, posterior fossa disease, spasm, trigeminal neuralgia, Jackson epilepsy, post-facial nerve palsy spasm, blepharospasm, cognitive impairment, speech disorder and dementia; (3) Had a history of severe hypertension, diabetes, or malignant tumors, serious diseases of heart, liver, kidney and other viscera; (4) Persons with metal residues (including dentures, pacemakers, nerve stimulators, medical pumps, etc.); (5) Those who are afraid of TMS and cannot stimulate TMS for other reasons; (6) Those who are afraid of acupuncture or have adverse reactions to acupuncture; (7) Pregnant or lactating women.

Design outcomes

Primary

MeasureTime frame
Motor evoked potentials (MEPs);

Secondary

MeasureTime frame
The resting motor threshold (rMT);Contralateral silent period (CSP);

Countries

China

Contacts

Public ContactLiu Jianhua

Department of Acupuncture and Moxibustion, Guangdong Provincail Hospital of Traditional Chinese Medicine

jyhf08@sina.com+86 13729889452

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026