cerebral small vessel disease
Conditions
Interventions
Sponsors
Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) The imaging performance on MRI includes one of the following manifestations: recent small subcortical infarcts, lacuna, white matter hyperintensity, microhemorrhage,brain atrophy and enlarged perivascular spaces. (2) Meet the "heat depression poison gathering" "Pulse stagnation" syndrome of traditional Chinese medicine diagnostic standards in the early stage of cerebral small vessel disease. (3) Aged 18-80 years, male or female. (4) Understand, agree to participate in this study and sign an informed consent.
Exclusion criteria
Exclusion criteria: (1) Large cerebral artery stenosis >= 50%. (2) Any hearing or visual impairment that can disturb efficient cognitive evaluation of the patient. (3) Massive cerebral infartion from cardioembolic source. (4) Any other white matter disease (i.e., multiple sclerosis, metabolic encephalopathy,toxic encephalopathy or multiple intracranial vasculitis). (5) Severe osteoarthritis and severe joint and muscle pain that may limit the patient's movement. Complicated with severe heart, liver, kidney, blood system and other diseases, or other serious primary diseases, mental illness. (6) Allergy to drugs in treatment programmes. (7) Pregnant or lactating women. (8) Patients who had participated in or were participating in other clinical trial the month before entering the group, or patients who had taken or were taking other medications for cerebral small vessel disease or Chinese herbal medicine with the same composition or the same effect as the tested Chinese herbal compound the month before entering the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TCM Syndrome Integr;ADL;tests for cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| glycometabolism;lipid metabolism;Microinflammation indicators; | — |
Countries
China
Contacts
Public ContactYan Han
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed