stroke
Conditions
Interventions
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed as ischemic stroke by clinical evaluation and comprehensive imaging examinations meet the diagnostic criteria for ischemic stroke; 2. Fugl-Meyer motor function score is confirmed as motor dysfunction; 3. Aged 18-70 years, no gender limit; 4. No cognitive impairment or communication impairment, with a score of 27 or more in the Simple Intelligence State Examination (MMSE); 5. The first onset, the course of illness is 2 days to January./ The first onset, the course of illness is from January to June. / Patients after nerve transfer.
Exclusion criteria
Exclusion criteria: 1. Those who have serious systemic diseases such as cardiopulmonary disease and cannot tolerate rehabilitation treatment; 2. Patients with diagnosed psychosis, major depression (suicidal tendency) or epilepsy, and those with family history of psychosis or epilepsy; 3. Existence of serious systemic diseases such as diabetes and uremia; 4. Severe joint contracture; 5. Suffer from any cause of consciousness disorder; 6. According to safety guidelines, there are contraindications for transcranial direct current/magnetic stimulation (TMS/tDCS) and functional magnetic resonance (fMRI) examinations such as: metal foreign bodies in the body or other electronic devices implanted in the body; 7. Defects in hearing or vision may affect assessment and treatment; 8. Use drugs that change the excitability of the cerebral cortex (antiepileptic drugs, sedative hypnotic drugs, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of Fugl-Meyer motor function score of affected upper limb; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electrophysiological testing of the upper limbs on the affected side: motor cortex evoked potential (TMS-MEP), central motor conduction time (CMCT), and cortical resting period (Silent Period) induced by transcranial magnetic stimulation;Daily life (behavioral) ability: International Classification of Functioning, Disability and Health (ICF) General Combination;Assessment of limb spasticity: modified Ashworth score (MAS);Functional Magnetic Resonance Detection: Including Task-design BOLD scan, Resting-state BOLD scan, brain structure phase scan and Diffusion Tensor Imaging (DTI);Functional Near Infrared Imaging (fNIRS);Physical balance: Berg balance scale;Limb motor function: upper limb WOLF motor function score, Fugl-Meyer motor function score; | — |
Countries
China
Contacts
Public ContactDongsheng Xu
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed