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A study of musk in the treatment of microcirculation disorder after PPCI in acute ST-segment elevation myocardial infarction

A study of the efficacy of musk in the treatment of microcirculation disturbance after PPCI in acute ST-segment elevation myocardial infarction

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2000003817
Enrollment
Unknown
Registered
2020-08-28
Start date
2020-10-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute ST-segment elevation myocardial infarction

Interventions

Sponsors

Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) AMI met WHO diagnostic criteria: persistent chest pain >30 minutes; Myocardial enzymes increased twice the normal value; St-segment elevation of two adjacent leads on the electrocardiogram >0.1mv; (2) Patients with first myocardial infarction; (3) Coronary angiography was performed to confirm complete occlusion of the criminal's blood vessels and direct PCI was performed; (4) All patients took aspirin, Bolivar, statins, lipid-lowering drugs and other drugs to inhibit in-stent restenosis as prescribed by the doctor after surgery; (5) No angina attack.

Exclusion criteria

Exclusion criteria: 1. Patients with coagulation dysfunction and severe liver and kidney dysfunction; 2. Patients with heart disease, severe pulmonary hypertension, uncontrolled hypertension, and adults with right-to-left shunt 3. Patients with suction distress syndrome; 4. With other heart diseases, such as rheumatic heart disease, congenital heart disease, etc.; 5. Severe arrhythmia, including frequent pre-ventricular contraction, paroxysmal ventricular tachycardia, atrial fibrillation; 6. A history of drug allergy.

Design outcomes

Primary

MeasureTime frame
TIMI myocardial perfusion framecount, TMPFC;Coronary Flow Reserve;Thrombolysis In Myocardial Infarction,TIMI;Symptomatology of Chinese medicine;cardiac function;ST segment recovery degree of ECG;index of microcirculatory resistance;

Countries

China

Contacts

Public ContactZheng Wang

Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine

zwnowayback@126.com+86 21 64385700

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026