primary biliary cholangitis
Conditions
Interventions
Sponsors
Shanghai chinese medicine hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Meet the above western medicine diagnostic criteria, AMA titer > 1:40; Alkaline phosphatase (ALP) > 1.5 times the upper limit of normal value or glutamyl transpeptidase b> 5 ULN lasting for 24 weeks or more. (2) Patients who meet the criteria for syndrome differentiation of liver depression and spleen deficiency in Traditional Chinese medicine are between 18 and 70 years old, regardless of gender. (3) Informed consent, sign informed consent and volunteer for the study.
Exclusion criteria
Exclusion criteria: (1) Pregnant or lactating women. (2) Patients with viral hepatitis or other hepatotropic virus infection, alcoholic liver disease, drug-induced liver injury, primary ssclerosis cholangitis, autoimmune hepatitis, Buga syndrome, hematopathy, Wilson's disease and other liver diseases; (3) Had used methotrexate, azathioprine or glucocorticoid in the 3 months before enrollment; (4) Evidence of intrahepatic or extrahepatic biliary tract obstruction; (5) Patients with liver failure or hepatorenal syndrome at baseline or after liver transplantation; (6) Patients with serious heart, liver, kidney or other complications or complicated with liver cancer or other malignant tumors or other serious primary diseases; (7) Those who have taken antibiotics in recent 2 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gamma-glutamyl transpeptidase;alkaline phosphatase;gut microbiota; | — |
Countries
China
Contacts
Public ContactRuan Jun
Shanghai Chinese Medicine Hospital
Outcome results
None listed