Chronic glomerulonephritis (CKD3 stage)
Conditions
Interventions
Sponsors
Shuguang Hospital affillated with Shanghai University of TCM
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 18 to 65 years; 2. Diagnosed with primary glomerulonephritis and included in the period of CKD G3; 3. 0.5g <= 24 h proteinuria <= 3.0g; 4. Blood pressure can be controlled under 140/90mmHg; 5. Severe infection, electrolyte disorders or acid-base disturbance can be controlled while the blood potassium value is within the normal range; 6. Traditional Chinese medicine syndrome conform liver-kidney yin deficiency; 7. Run-in period: two weeks. At the beginning and end of the run-in period, patients must undergo the following tests twice, and only those who meet the standards can enter the trial. GFR: 3059 mL/min/1.73m2, 0.5g <= 24 h proteinuria <= 3.0g, Bp <= 140/90 mmHg; 8. Obtain the agreement of patients, and signed informed consent file.
Exclusion criteria
Exclusion criteria: 1. Henoch-Schonlein purpura nephritis, lupus nephritis, systemic small vasculitis kidney damage, gouty nephropathy, Myeloma nephropathy and other secondary nephropathy; 2. Take the glucocorticoid, immunosuppressants and triptolide medications in the last 3 months; 3. Take other Chinese patent medicine and decoction whicn can reduce proteinuria in the last 2 weeks; 4. Combined with severe primary disease of heart, brain, liver and hematopoietic system, or other serious diseases can affect patients life; 5. Pregnant or lactating women; 6. Allergic predisposition or known to be allergic to the drug composition; 7. Blood presser < 90/60mmHg; 8. Patient with unilateral or bilateral renal artery stenosis; 9. Patients with mental disorders and poor compliance; 10. Patiens are suspected or confirmed with alcohol, drug abuse history; 11. Patines who is participating in another clinical study at the same period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24 hours Proteinuria; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood urea nitrogen;Serum creatinine;Urine albumin-to-creatinine ratio;eGFR; | — |
Countries
China
Contacts
Public ContactLin Xu
Shuguang Hospital affillated with Shanghai University of TCM
Outcome results
None listed