Severe pneumonia
Conditions
Interventions
Sponsors
LongHua Hospital Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years old, both male and female; 2. They met the diagnostic criteria of severe pneumonia; 3. The diagnostic criteria of SIRs were met; The diagnostic criteria of myocardial injury were met; 5. It is in accordance with the diagnostic standard of TCM syndrome of "heat sink pericardium, toxin and bruise collaterals"; 6. The family members of the patients knew the purpose of the study, signed the informed consent and voluntarily participated in the study.
Exclusion criteria
Exclusion criteria: 1. The diagnosis of severe pneumonia was more than 48 hours; 2. Pregnant, lactating and pregnant women; 3. Other non infectious lung diseases, such as pulmonary tumor, obstructive pneumonia caused by pulmonary tuberculosis, etc; 4. Diseases that may seriously affect the survival of primary diseases, such as unresectable tumors, hematologic diseases, long-term bed rest caused by cerebrovascular diseases, Alzheimer's disease or AIDS; 5. Using immunosuppressants, hormones (cumulative total dose of methylprednisolone >= 1500 mg) and / or cytotoxic drugs in the past 6 months, or use all of the above drugs in the previous 7 days; 6. Chemical pneumonia, interstitial pulmonary fibrosis, alveolar proteinosis, allergic alveolitis; 7. Patients with severe mental illness; 8. Allergy (allergic to two or more substances, or allergic to medication in this study); 9. patients with acute or massive bleeding and bleeding tendency; 10.Myocardial infarction and cardiomyopathy were found in 103 months; 11. Acute heart failure or cardiopulmonary resuscitation occurred within 1 week after admission; 12. patients with valvular heart disease and congenital heart disease; 13. Chest injury or cardiac surgery was performed in 136 months; 14. Participate in other clinical trials 30 days before 14; 15. Patients with severe acute respiratory distress syndrome; 16. Other patients who, according to the judgment of the investigator, are not suitable for the trial or cannot complete the follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pneumonia Severity Index;cTNI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Apache? Score;Blood gas analysis;Cardiac ultrasound;EKG;routine blood test;TCM syndrome score;Myocardial zymogram;BNP;MODS score;Mortality at day 28;Sputum culture;Improvement of SIRS;SOFA Score;Chest X ray;Lung Injury Score;CRP; | — |
Countries
China
Contacts
Public ContactZhang Yiyi
LongHua Hospital Shanghai University of Traditional Chinese Medicine
Outcome results
None listed