Knee osteoarthritis
Conditions
Interventions
Sponsors
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Patients with knee osteoarthritis who meet the diagnostic criteria of Western medicine and TCM syndrome differentiation; (2) Aged 40-70 years old male and female; (3) KL grade was 0-3; (4) VAS score >=4; (5) The subjects had informed consent and signed the informed consent voluntarily.
Exclusion criteria
Exclusion criteria: (1) KL grade 4; (2) Other inflammatory and painful diseases of knee joint, such as rheumatoid arthritis, psoriatic arthritis, gout, tumor, joint trauma, suppurative arthritis, etc; (3) Knee osteoarthritis caused by osteomyelitis, bone tumor and bone tuberculosis; (4) Patients with pyogenic and nonspecific infectious knee osteoarthritis were found; (5) The patients with advanced joint deformity or disability; (6) Intra articular treatment including intra-articular injection of drugs, intra-articular irrigation and arthroscopic surgery were performed within 3 months before the trial; (7) Patients with multiple lower extremity osteoarthritis of hip, knee and ankle had lower limb pain due to the onset of lumbar degenerative disease; (8) Alt >=1.5 ULN, abnormal Cr contration; (9) Pregnant or lactating women; (10) People with allergic constitution or allergic to this drug; (11) Patients with severe cardiovascular and cerebrovascular diseases, blood system, liver, gastrointestinal tract, kidney disease and diabetes mellitus; (12) Mental patients; (13) Those who have used hormone therapy within one month; (14) Those who have used other drugs for the treatment of knee osteoarthritis within one week before the trial, such as non steroidal anti-inflammatory drugs, benzothiazides, glucosamine, chondroitin sulfate and related traditional Chinese medicine; (15) Long term use of other drugs that affect the efficacy and safety of the trial drug and take comprehensive treatment; (16) Patients who have participated in other clinical trials within three months; (17) The researchers consider that it is not suitable to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score;WOMAC total score and pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| WOMAC stiffness score, joint activity score; | — |
Countries
China
Contacts
Public ContactGuo Hailing
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed