Influenza in Children
Conditions
Sponsors
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
5 Years to 14 Years
Inclusion criteria
Inclusion criteria: (1) Patients diagnosed with influenza A (H1N1, H3N2) or influenza B virus according to real-time polymerase chain reaction (PCR) or virus culture; (2) Aged 5 to 14 years; (3) Armpit temperature >= 38 degrees C; (4) At least 2 systemic symptoms (headache, chills, myalgia or fatigue) and 1 respiratory symptom (cough, sore throat or rhinitis); (5) Those who meet the diagnostic criteria of TCM syndromes; (6) The course of the disease is within 72 hours; (7) Sign a written informed consent.
Exclusion criteria
Exclusion criteria: (1) Bronchitis, pneumonia, pleural effusion and interstitial lung disease confirmed by chest imaging (x-ray examination or CT); (2) Blood routine examination indicated bacterial infection; (3) purulent tonsillitis or purulent sputum; (4) Having primary diseases, such as blood diseases, bronchial asthma, liver diseases, kidney diseases, chronic congestive heart failure, and neurological diseases; (5) Antiviral drugs (amantadine, rimantadine, zanamivir or oseltamivir phosphate) were taken before the onset and inclusion of the study, or Chinese herbal medicines or proprietary Chinese medicines were taken. (6) Allergic to research drugs; (7) Take immunosuppressants within the last 3 months; (8) Participate in another clinical trial < 3 months prior to study randomization; (9) Acute respiratory infection, otitis or sinusitis 2 weeks before study inclusion; (10) Influenza vaccination within 6 months; (11) Other reasons suggested by the researchers. See Table 4 for inclusion and exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of cure;Defervescence time;Duration of disease; | — |
Secondary
| Measure | Time frame |
|---|---|
| The time between the start of treatment and the return to normal life (kindergarten or school);Disease severity;TCM syndrome score;Incidence of influenza complications;Frequency of use of antipyretic;Negative conversion rate of influenza virus; | — |
Countries
China
Contacts
Public ContactWang Xue-Feng
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
Outcome results
None listed