Acute ischemic stroke
Conditions
Sponsors
Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients who meet the diagnosis of acute ischemic stroke and TOAST classification does not belong to cardiogenic cerebral embolism (SE); 2) The onset time <=72 hours (within 72 hours from onset to random drug use); 3) Persons between 18 and 85 years of age, regardless of gender; 4) Patients with recurrent onset of first onset or sequela of limb paralysis with mRS score 0 ~ 1 points of previous cerebrovascular disease; 5) NIHSS score 4 to 25, mild, moderate, and severe patients; 6) Those who voluntarily accept the drug treatment and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) Those who do not meet the inclusion criteria; 2) Patients with transient ischemic attack, lacunar cerebral infarction with non-responsible lesions, cerebral hemorrhage after cerebral infarction, subarachnoid hemorrhage and posterior circulation ischemia; 3) Hemiplegia caused by brain tumors, brain trauma, brain host worms, metabolic disorders, cerebral embolism caused by rheumatic heart disease, coronary heart disease and other heart diseases combined with atrial fibrillation after examination; 4) Thrombolytic patients; 5) Patients with digestive tract ulcers who cannot take aspirin; Those with bleeding tendency; Patients with severe primary diseases such as cardiovascular disease, liver (ALT or AST > 1.5 ULN, kidney (eGFR < 60), endocrine system and hematopoietic system; 6) Pregnant and lactating women; 7) Those who are known to be allergic to the drugs used; 8) Those who are participating in other drug clinical trials or have participated in other clinical trials within 3 months; 9) Patients whom the investigator considers inappropriate to participate in a clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Homocysteine;IL-6;NIHSS score;Barthel index;TXB2;TNF-a;PG1a;Chinese medicine stroke score table;Fibrinogen;Prothrombin time;Vascular endothelial growth factor;Modified RANKIN scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dung conventional;Alanine transaminase (ALT);Aspartate transaminase (AST);Routine blood;Routine urine;Creatinine;Myocardial enzyme spectrum; | — |
Countries
China
Contacts
Public ContactCao Min
Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed