Precocious Puberty
Conditions
Interventions
Sponsors
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Those who met the diagnostic criteria of peripheral precocious puberty, had abnormal sex hormone, B-ultrasound and X-ray examination, but the sex hormone provocation test did not meet the diagnosis of true precocious puberty; (2) In addition to the main symptoms, it was accompanied by five heart trouble, hot flushes, fear of heat, red cheekbones, night sweats, irritability and irritability, dry throat and dry mouth, short yellow urine, dry stool, or no moss and thin pulse. (3) The age of onset was less than 8 years in girls and 9 years in boys; (4) Girls have not menarche, and their bone age is less than 11 years old or (bone age age age) < 2 years old; boys have no ejaculation and their bone age is less than 13 years old; (5) Those who sign informed consent.
Exclusion criteria
Exclusion criteria: (1) True precocious puberty caused by intracranial organic lesions; (2) Pseudoprecocious puberty, including adrenal or ovarian tumors, fibrous dysplasia associated with precocious puberty syndrome, ingestion of Estrogen; (3) Precocious puberty of the opposite sex; (4) Tanner IV and with menses; (5) Previous history of mental illness or severe heart, brain or neurological disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| labia coloration;pulse;Serum sex hormones;Vaginal discharge;weight;Size of breast and areola;Size of mastoid nucleus;coating on the tongue;Growth of pubic and axillary hairs;height;Growth rate of height;Bone age and predicted height;BMI;TCM syndrome score;Volume measurement of uterus and ovary;Serum ALT, BUN, Cr; | — |
Countries
China
Contacts
Public ContactJian Shen
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed