Postoperative cognitive dysfunction, POCD
Conditions
Interventions
control group:None
Sponsors
The Second Affiliated Hospital of Air Force Medical University (Tangdu Hospital)
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) Patients are scheduled for thoracoscopic radical resection for lung cancer which may last more than 2 hours; 2) Patients aged 65–90 years; 3) BMI: 18-30kg/?; 4) American Society of Anesthesiologists status I to III; 5) Primary tumor, never had radiotherapy or chemotherapy before; 6) Conduct pulmonary sequestration with a double-lumen tube; 7) Patients are voluntary to sign informed consent form.
Exclusion criteria
Exclusion criteria: 1) Patients with communication disorders such as language comprehension disorder, mental disorders, epilepsy, history of Parkinson's disease or myasthenia Gravis and so on; 2) History of opioid, alcohol or other drug abuse and addiction; 3) Patients with TEAS contraindications including partial damaged skin, infection or implantable internal electrophysiologic device; 4) History of unstable angina pectoris or myocardial infarction within 3 months; NYHA >= III; 5) Pre-existing hypertension (systolic pressure >= 180 mmHg and/or diastolic pressure >= 110 mmHg), WHO-ISH III; 6) Patients with pre-existing complications of diabetes such as diabetic ketoacidosis, diabetic hyperosmolar coma, kinds of infections, macroangiopathy, nephrosis, retinopathy, diabetic cardiopathy, diabetic neuropathy, diabetes feet and so on; 7) Patients with hepatic and renal insufficiency (Severe abnormality of hepatic function: Of ALT, CB, AST, ALP and TB, one if is twice more than the normal upper limit; Severe abnormality of renal function: Cr 177umol/L); 8) COPD: GOLD III or IV, Lung fibrosis, Uncontrolled asthma; 9) History of pulmonary operation; 10) Unilateral pulmonary resection or bilateral pulmonary operation; 11) Massive hemorrhage in operation; 12) Taking pulmonary sequestration ways such as difficult airway, tracheotomy, occluder, artificial pneumothorax excluded DLT ; 13) Patients took part in other clinical trials within 3 months; 14) The physician in charge or the researcher considers that patients with other inappropriate circumstances in this study (reasons should be recorded).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative cognitive function scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood gas analysis;analogue scale scores of pain;intraoperative inflammatory reaction;incidence of postoperative complications; | — |
Countries
China
Contacts
Public ContactChangjun Gao
The Second Affiliated Hospital of Air Force Medical University
Outcome results
None listed