Acneiform Rash Induced by Anti-tumor Targeted Drugs
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male or female patients aged >18 years; 2. Patients receiving anti-tumor targeted drugs; 3. Grade III rash according to NCI-CTC 5.0 standard; 4. KPS > 60, life expectancy >=3 months; 5. The functional level of major organs met the following criteria: 1) ANC (> 1.5 *10^9/L), PLT (> 75 *10^9/L), Hb (> 80 g/L); 2) TBIL 50 ml/min) (Cockcroft-Gault formula); 6. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Life expectancy < 3 months 2. Skin lesions or skin diseases considered to affect the study, or history of allergic contact with other drugs; 3. Received hormones or antibiotics or any other drugs that may affect the skin rash within 1 week before the start of our research, including Chinese patent medicine and herbal medicine; 4. Serious or uncontrollable systemic diseases (such as unstable respiration, circulation, digestion, urinary and blood system diseases, ect); 5. Any unstable systemic diseases (including active infection, grade III hypertension, unstable angina pectoris, congestive heart failure, or metabolic diseases, etc.); 6. Previous history of neurological or mental disorders, including epilepsy and dementia; 7. Pregnancy or lactation; 8. The subject was considered not be able to complete the study or comply with the requirements of this study (due to management or other reasons).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Partial response rate;Changes of rash classification;Average remission time;Total effective rate;Cure rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life assessment;Average recurrent time;Safety evaluation;Recurrence rate; | — |
Countries
China
Contacts
Public ContactQijin Shu
The First Affiliated Hospital of Zhejiang Chinese Medical University
Outcome results
None listed