gastric cancer
Conditions
Interventions
Sponsors
Jiangsu Province Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Patients with pathological diagnosis of Gastric cancer; 2. The TNM stage was III-IV; 3. Patients with dysfunction of blood coagulation and meet the two following criteria: (1) PT shortening > 3s; (2) APTT shortening > 3s; (3) FIB > 4g/L; 4.DD > 0.5mg/l; 5.PLT > 300 * 10^9 / L; 4. Patients with criteria of TCM syndrome of blood stasis and weakened spleen and stomach; 5. Patients aged from 18 to 80 years old; 6. KPS score > 50; 7. Patients with life expectancy of at least 3 months; 8. No hemostasis, thrombolysis, anticoagulation, antiplatelet, non steroidal anti-inflammatory drugs or traditional Chinese medicine which effected of promoting blood circulation has been taken in the two weeks before admission; 9. Patients who provide written informed consent to participate in the study according to the GCP criteria.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Patients who is unable to swallow oral medications including with digestive tract obstruction and jejunostomy; 2. Patients with symptomatic brain metastasis or mental disorder; 3. Patients with severe cardiovascular disease, chronic liver disease, kidney disease or blood disease; 4. Patients with active bleeding (massive bleeding) or bleeding tendency; 5. Patients with serious uncontrolled medical diseases or acute infection; 6. Patients whose laboratory examination before enrollment is abnormal according to the following criteria: Blood routine examination: ANC 1.5 * upper normal limit (UNL); CCr 1.5 * UNL, ALT(SGPT) and AST (SGOT) > 1.5 * UNL; 7. Patients who are pregnant, nursing; 8. Patients who are substance abuse, or with clinical, mental, and social features which is interference for the study and informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| inflammatory factors(IL-1ß\IL-8\IL-10\TNF-a\GM-CSF);VEGF;Tissue Factor; | — |
Secondary
| Measure | Time frame |
|---|---|
| platelet aggregation test with turbidimetry;Seven Items of Blood Coagulation;Karnofsky;complete blood count; | — |
Countries
China
Contacts
Public ContactLing Bofan
Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine
Outcome results
None listed