Coronary microvascular dysfunction
Conditions
Interventions
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) 18-80 years old patients, both male and female; 2) Selective coronary angiography or coronary CTA showed that the diameter of coronary artery was = 2.5mm, the degree of vascular stenosis was < 50%, and there was no myocardial bridge; 3) They were able to do treadmill exercise and had positive results in treadmill test (EET); 4) There were angina pectoris symptoms; 5) The patients were willing to follow up and sign informed consent; All the above criteria should be met.
Exclusion criteria
Exclusion criteria: 1) Coronary heart disease complicated with hypertrophic cardiomyopathy; 2) Patients with AMI, PCI, CABG history, cardiac myobridge or CTA in angiographic results; 3) Patients with severe medical diseases (liver, kidney, hematopoietic system and other serious primary diseases); 4) Mental disorders and mental disorders; 5) Patients with pulmonary failure and NYHA cardiac function grade III-IV who can not carry out exercise test; 6) The contraindications of Shexiang Baoxin Pill: forbidden for pregnant women; 7) Those who have been known to be allergic to Shexiang Baoxin Pills; 8) Recently, patients have regularly taken Shexiang Baoxin Pills and other anti ischemic Chinese medicines, or contain borneol, Bufonis and other ingredients in Shexiang Baoxin Pills; 9) The results showed that frequent ventricular premature beats, ventricular tachycardia, atrial fibrillation, sinoatrial block, atrioventricular conduction block, left bundle branch block and right bundle branch block may affect the judgment of exercise electrocardiogram results; 10) There are other factors that are not suitable to participate in the experiment; One of the exclusion criteria can be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| At the end of the treatment, the heart rate abnormal recovery rate (HRR) between Shexiang Baoxin Pill group and placebo group during exercise treadmill ECG test was different; | — |
Secondary
| Measure | Time frame |
|---|---|
| At the end of the treatment, the abnormal response rate of blood pressure between Shexiang Baoxin Pill group and placebo group in treadmill ECG test was different; | — |
Countries
China
Contacts
Public ContactYanqiu Chen
Shanghai Hutchison Pharmaceuticals
Outcome results
None listed