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Study on miR21--ECP--IL-4 network and miR21 target gene regulation mechanism of allergic rhinitis with Qi deficiency and Blood stasis syndrome by Ke-Min-Qi-Dan nasal spray

To explore the regulation mechanism of the target gene miR21 and miR21--ECP--IL-4 network of allergic rhinitis with qi deficiency and blood stasis syndrome by Ke-Min-Qi-Dan nasal spray: a single-center, prospective, randomized controlled clinical trial

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2000003471
Enrollment
Unknown
Registered
2020-07-06
Start date
2020-07-16
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

allergic rhinitis with qi deficiency and blood stasis syndrome

Interventions

Sponsors

The Hospital of Chengdu University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) In accordance with the diagnostic criteria of western medicine for allergic rhinitis; (2) In accordance with the diagnostic criteria of traditional Chinese medicine of qi deficiency and blood stasis syndrome; (3) Those who have not received any treatment in the past week; (4) Age between 18 and 65, regardless of gender; (5) Those who agree to participate in this project and sign informed consent.

Exclusion criteria

Exclusion criteria: (1) Patients with severe diseases of brain, heart, kidney, digestive system and hematopoietic system.And the mentally ill; (2) Patients with severe chronic rhinitis, significantly deviated nasal septum, or severe nasal polyps, sinusitis, or asthma; (3) Patients who have received or are receiving immunospecific therapy; (4) Intended pregnant women, pregnant women or lactating women; Patients with any of the above are excluded.

Design outcomes

Primary

MeasureTime frame
platelet-activating factor;interleukin4;Phosphatase and tensin homologue deleted on chromosome 10;microRNA-21;eosinophilcationicprotein;

Secondary

MeasureTime frame
Phosphatase and tensin homologue deleted on chromosome 10;Visual simulation scale;

Countries

China

Contacts

Public ContactTian Li

The Hospital of Chengdu University of Chinese Medicine

18980880129@qq.com+86 18980880129

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026