gallstone disease
Conditions
Interventions
Sponsors
Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Subjects with gallstone diseases 1.meet the diagnostic criteria for gallstone disease set by the EASL in 2016; 2.aged between 18 and 60 years and right-handed; 3.have not taken any cholagogic drugs within 1 month; 4.not participating in any other clinical trials in the past three months; 5.having signed informed consent Subjects after cholecystectomy 1.for cholelithiasis (cholecystolithiasis), cholecystectomy (preservation of extrahepatic bile duct) has been performed for at least one year; 2.there was no post cholecystectomy syndrome such as upper or right upper abdominal pain, postprandial abdominal distension, dyspepsia, biliary tract infection or biliary obstruction in the past 3 months; 3.aged between 18 and 60 years and right-handed; 4.after physical examination, all physiological indexes were in the normal range. There was no functional or organic disease and no head injury; 5.there was no family history of mental and nervous system; 6.the subjects signed the paper informed consent form and voluntarily participated in the experiment. 7.subjects who meet all the above inclusion criteria will be considered for inclusion. Healthy subjects 1.aged between 18 and 60 years and right-handed; 2.after physical examination, all physiological indexes were in normal range, and there was no functional or organic disease and no head injury; 3.no family history of mental and nervous system; 4.the subjects signed the paper informed consent form and volunteered to participate in the experiment. 5.healthy subjects who meet all the above inclusion criteria will be considered for inclusion
Exclusion criteria
Exclusion criteria: Subjects with gallstone diseases (1) calculus in bile duct; (2) acute cholecystitis, acute suppurative, gangrenous, incarcerated cholecystitis and perforation of gallbladder with diffuse peritonitis, etc; (3) with serious complications or primary diseases such as cardiovascular, liver, kidney, endocrine and hematopoietic system; (4) with severe digestive system diseases, such as peptic ulcer, upper gastrointestinal hemorrhage, gastric tumor, Crohn's disease, irritable bowel syndrome, etc; (5) WBC > 12 * 10^9/L with systemic inflammatory response; (6) having a history of corticosteroid treatment in the past month; (7) having a history of anti-infective drug therapy (excluding cephalosporins) in the past month; (8) with high anxiety and depression (SAS >= 70 or SDS >=72) and those with mental illness; (9) with obvious headache, migraine, head injury history and obvious pain in other parts; (10) women being in pregnancy or lactation; or (11) having contraindications of MRI scans such as claustrophobia or implanted ferromagnetic metal; (12) with head space occupying disease. Subjects after cholecystectomy (1) pregnant or lactating women; (2) patients with obvious history of headache, migraine and head trauma; (3) those who have contraindication of fMRI acquisition; (4) those who are participating in other clinical trials;(5)patients who meet any of the above items will be excluded. Healthy subjects (1) pregnant or lactating women; (2) patients with obvious history of headache, migraine and head trauma; (3) those who have contraindication of fMRI acquisition; (4) those who are participating in other clinical trials; (5) patients who meet any of the above items will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| task fMRI data; | — |
Secondary
| Measure | Time frame |
|---|---|
| Numeric Rating Scale;appetite test; | — |
Countries
China
Contacts
Public ContactSun Ruirui
Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine
Outcome results
None listed