heart failure with mid range ejection fraction
Conditions
Interventions
Sponsors
Hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-75 years; 2. Newly discovered patients with chronic heart failure are treated with stable and standardized guidelines for more than 3 months; 3. Meet the diagnostic conditions of HFmrEF: (1) Have symptoms and/or signs of heart failure; (2) LVEF40%49%; (3) Increased natriuretic peptide levels (B-type brain natriuretic peptide, BNP >= 35 pg/ml or N-terminal BNP precursor, NT-proBNP >=125 pg/ml) (4) Related structural heart diseases: left ventricular hypertrophy (male left ventricular mass index >= 115g/m2, female >= 95g/m2) or left atrial enlargement (left atrial volume index > 34ml/m2) or diastolic dysfunction. 4. After more than two weeks of the washout period of Chinese medicine/Chinese patent medicine; 5. Heart failure caused by hypertension and underlying coronary heart disease; 6. Patients with cardiac function grade NYHA II/III; 7. Agree and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Heart failure is accompanied by severe heart valve disease, congenital heart disease, pericardial disease, cardiomyopathy, acute cardiovascular events in the past month, unstable angina, acute myocarditis and infective endocarditis; 2. Cerebrovascular accident and severe pulmonary vascular disease occurred in the last 6 months; 3. Severe liver and kidney dysfunction, in which creatinine > 265µmol/L 4. Merging serious diseases or malignant tumors of other systems; 5. Women who are pregnant or breastfeeding or have recent birth planning; 6. People with allergies, mental illnesses and infectious diseases; 7. Acute infection, sepsis and sepsis; 8. Known intolerance to long-term use of Chinese medicine; 9. Patients who are participating or have participated in other clinical trials within the past three months; 10. The investigator believes that it is not appropriate to participate in other conditions of this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Six-minute walk test;NYHA functional class;adverse cardiovascular events;Left ventricular ejection fraction;N-Terminal pro-brain natriuretic peptide (NT-proBNP); | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure;blood routine examination;liver faction examination;Electrocardiogram;routine urine examination;SF-36 Quality of Life Questionnaire; | — |
Countries
China
Contacts
Public ContactXueping Li
Hospital of Chengdu University of Traditional Chinese Medicine
Outcome results
None listed