Ankylosing spondylitis
Conditions
Interventions
Sponsors
Jiangsu Province Hospital of TCM
Eligibility
Sex/Gender
All
Age
25 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. diagnosed as ankylosing spondylitis: meet the AS New York Standard revised in 1984 or the Central Axis SpA classification standard recommended by the International Society for the Treatment of Spondylitis (ASAS) in 2009; 2. Married, bred, no fertility requirement within one year; 3. aged between 25 and 70 years old; 4. TCM syndrome differentiation is in accordance with the syndrome of kidney deficiency and coldness in Du Meridian [Refer to the "Guidelines for Clinical Research of New Drugs in Traditional Chinese Medicine" promulgated in 2002, the "Reference Standard for Syndrome Differentiation of Traditional Chinese Medicine" formulated by the National Committee of Integrative Medicine for Deficiency of Chinese Medicine and Western Medicine, and the "Criteria for Syndrome Differentiation of Traditional Chinese Medicine" edited by Professor Deng Tietao.]: Main symptoms: lumbosacral,stiffness and uncomfortable feeling in lower back, limited activity such as pitching; weakness of waist and knees; avoid of coldness, and comfortable with warmness. Secondary symptoms: the extremities are not warm;loose stool;the scrotum is wet and cold, impotence, and soreness of waist and knees;clear urine or more frequent during the nighttime. Tongue and pulse:pale tongue, thin white coating and deep thready pulse. Two main symptoms are necessary, combined with secondary symptoms, tongue and pulse.
Exclusion criteria
Exclusion criteria: 1. Those who have not given birth or have fertility requirement within one year; 2. History of using any NSAIDs and DMARDs within 12 weeks; 3. Blood WBC <3.5x10^9/L; alanine aminotransferase is more than twice the normal value; 4. Combined with serious primary diseases such as cardiovascular, tumor, kidney, liver and hematopoietic system; 5. Hepatitis B patients; 6. Psoriasis, Crohn's disease, ulcerative colitis, recent onset of ophthalmia; 7. Unable to cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ASAS20, 40;BASDAI;ASDAS; | — |
Secondary
| Measure | Time frame |
|---|---|
| ESR;Metabolomic changes in serum;CRP; | — |
Countries
China
Contacts
Public ContactJi Wei
Jiangsu Province Hospital of TCM
Outcome results
None listed