A study of resting brain function MRI and neurocognitive function in different degree of depression attack of liver depression

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ITMCTR

Registry ID

ITMCTR2000003403

Enrollment

Unknown

Registered

2020-06-17

Start date

2020-07-01

Completion date

Unknown

Last updated

2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Syndrome of liver depression

Interventions

normal group vs. liver depression syndrome group:N/A

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Normal volunteers: (1) The age is 18-60 years old, male and female are not limited. (2) The routine physical examination was carried out and all the examinations were normal. (3) The score of Hamilton Depression Symptom Scale (HAMD-17) is less than 7, which is not in accordance with the classification and diagnosis criteria of depression in the guide manual of psychiatric diagnosis (ICD-10). (4) No antidepressants or psychoactive drugs were taken within 2 weeks before the examination. (5) Volunteer and sign informed consent. Patients with liver depression syndrome: (1) The age is 18-60 years old, male and female are not limited. (2) First episode of depression. (3) The score of Hamilton Depression Symptom Scale (HAMD-17) is more than 17, and it is in accordance with the classification and diagnosis criteria of depression in the guide manual of psychiatric diagnosis (ICD-10). (4) "TCM Constitution identification software" indicates that liver qi stagnation results in constitution, and conforms to the dialectical classification of TCM liver depression syndrome. (5) No antidepressants or psychoactive drugs were taken within 2 weeks before the examination. (6) Volunteer and sign informed consent.

Exclusion criteria

Exclusion criteria: (1) Patients with serious brain organic diseases and body diseases. (2) Those who cannot cooperate with the inspection. (3) Those who are inclined to commit suicide or self injury. (4) People who have taken antidepressants or psychoactive drugs before. (5) Family history of depression and other family history related to induced psychosis.

Design outcomes

Primary

Measure	Time frame
Brain MRI;	—

Secondary

Measure	Time frame
Degree of depression;	—

Countries

China

Contacts

Public ContactDanian Li

The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine

qylidanian@163.com+86 13318700493

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026