Postoperative delirium
Conditions
Interventions
Sponsors
Guangdong Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients undergoing total knee arthroplasty under general anesthesia; 2. Patients over 65 years old; 3. The American anesthesiologist's Book Writing (ASA) was classified as I-III patients; 4. MMSE score before operation: primary school education >=20 points, middle school education >=22 points, university education >=24 points; 5. Patients who agree to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with serious psychosis, hematopoietic system disease, malignant tumor and other major diseases; 2. Patients with previous serious heart and lung diseases; 3. Patients taking antipsychotic drugs irregularly for a long time before operation; 4. Patients with obvious hepatorenal diseases or alt, AST higher than 1.5 ULN, Cr, bun higher than ULN; 5. Patients with severe coagulation dysfunction who could not be corrected; 6. Patients with previous history of fainting; 7. Long term alcoholics; 8. Patients with mental disorders or language communication difficulties; 9. Other subjects that the researchers think are not suitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of waking or postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of vomiting, nausea and postoperative pain;Changes of hypersensitive C-reactive protein, cortisol and neuron-specific enolase NSE;Nu-DESC score;VAS score;CAM-CR score; | — |
Countries
China
Contacts
Public ContactXin Xiong
Guangdong Hospital of Traditional Chinese Medicine
Outcome results
None listed