The cortical excitatory response by monophasic pulse waveform electroacupuncture predicts potential on the upper extremity recovery in patients with acute stroke

Effect and mechanism of electroacupuncture combined with repeated transcranial magnetic stimulation in the individualized treatment of cerebral infarction with upper extremity motor dysfunction

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ITMCTR

Registry ID

ITMCTR2000003361

Enrollment

Unknown

Registered

2020-05-28

Start date

2019-04-01

Completion date

Unknown

Last updated

2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

None listed

Eligibility

Sex/Gender

All

Age

30 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Patients meet the diagnostic criteria of cerebral infarction with integrated Chinese and western medicine; (2) Patients diagnosed with cerebral infarction with upper limb movement dysfunction by MRI or CT; (3) Patients aged 30 to 80 years old male and female; (4) No limitation on the degree of limb dysfunction within 1 week after the first onset of disease course; (5) Clear consciousness without obvious aphasia or cognitive dysfunction; (6) No limb deformity, motor dysfunction or sensory dysfunction before onset; (7) Without skull defect or other physical diseases, and can withstand the detection for 1h; (8) Sign informed consent.

Exclusion criteria

Exclusion criteria: (1) Patients with subarachnoid hemorrhage, cerebral embolism, lacunar cerebral infarction and cerebral trauma, who have serious systemic diseases such as cardiopulmonary diseases and cannot tolerate rehabilitation treatment; (2) Patients with more than two or more cerebral infarction, or with cognitive, verbal, psychological, mental, visual and auditory disorders; (3) Contraindication of transcranial magnetic stimulation (TMS) and magnetic resonance (MRI) examination, such as pacemaker, metal implant, etc., in pregnant or lactating women; (4) Patients with motor dysfunction before onset should apply drugs (antiepileptic drugs, sedative and hypnotic drugs, etc.) to change the excitability of cerebral cortex; (5) Pregnant or lactating women.

Design outcomes

Primary

Measure	Time frame
120%resting motor threshold ;short-interval intracortical inhibition;Fugl-Meyer motor assessment of the upper extremity;short-interval intracortical inhibition;motor evoked potential (MEP);	—

Secondary

Measure	Time frame
shoulder abduction and finger extension;The National Institutes of Health Stroke Scale;	—

Countries

China

Contacts

Public ContactChunlei Shan

Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine

zhongyb2010@163.com+86 18201826956

Outcome results