Osteoarthritis of knee
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet the stage I, II, III of Kellgren-Lawrecne's radiological diagnostic criteria; 2. KAS pain VAS score >= 4 points; 3. The age is between 40-70 years old, regardless of gender; 4. Those who have not taken other related treatment drugs or adopted related treatment measures within 2 weeks; 5. Participate voluntarily, sign the informed consent form, be willing to accept the trial, and follow the random grouping.
Exclusion criteria
Exclusion criteria: 1. Women who are pregnant or breastfeeding, or who have a pregnancy plan during the trial; 2. Patients with severely life-threatening cardiovascular and cerebrovascular diseases, liver, kidney, hematopoietic system and other diseases or infectious diseases, who are unable to complete or are not suitable for related treatment and examination; 3. Patients with local infection, ulceration, vascular nerve injury or deep abscess in the knee; 4. Patients who have a history of severe knee trauma, or have undergone surgery or arthroscopy treatment; 5. Patients with other bone diseases such as tuberculosis, tumors, rheumatism, rheumatoid arthritis, gouty arthritis and other bone diseases that are not osteoarthritis or knee pain caused by other diseases; 6. Patients who have received oral hormonal drugs or knee closure therapy and other interventions within 1 month; or patients who have participated in other clinical trials within 3 months; 7. People who are allergic to the medical devices involved in this trial; contraindications to the use of indomethacin plaster, such as those with a history of allergy to indomethacin, those with liver and kidney dysfunction (alanine aminotransferase (ALT), aspart The amino acid transaminase (AST) is more than 2 times the normal value, and the blood creatinine (cr) is more than the normal value). Patients who have induced asthma, urticaria or allergic reactions after taking aspirin or other non-steroidal anti-inflammatory drugs may have nonsteroidal Patients with a history of gastrointestinal bleeding or perforation after anti-inflammatory drugs, patients with active gastrointestinal ulcer bleeding, or patients with previous recurrent ulcers / bleeds, patients with severe heart failure, perioperative coronary artery bypass surgery, etc .; 8. Patients with bleeding tendency, such as long-term use of anticoagulants such as warfarin and aspirin; 9. Those who have a history of sedative hypnotics, opioid analgesics and alcohol abuse; 10. Patients with cognitive impairment, or language communication impairment, unable to express accurately.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC knee osteoarthritis score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient's knee mobility measurement;Patient's knee musculoskeletal ultrasound;Patient's knee X-ray examination;Patient pain score (VAS);Patient's knee circumference measurement;Patient's plantar pressure test; | — |
Countries
China
Contacts
Public ContactZheng Liang
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed