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Active and passive intervention conbined with characteristic treatment regimens of traditional Chinese medicine in mild cognitive impairment: a multicentre, randomized control study

Research on health state intervention by active and passive ways and management techniques based on the combination of traditional Chinese medicine constitution (subtopic 3) : clinical evaluation of intervention techniques for subthreshold depression, insomnia and mild cognitive impairment

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2000003223
Enrollment
Unknown
Registered
2020-04-19
Start date
2020-05-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild cognitive impairment

Interventions

Sponsors

Beijing University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients meeting MCI diagnostic criteria; According to the MCI diagnostic criteria developed by the National Institute of aging (NIA) and the Alzheimer's Association (ADA) in 2011: (1) Memory function decreased; (2) The continuous decline of cognitive function lasted from several months to one year; (3) Excluding Parkinson's disease and hallucinations; (4) Imaging showed that there were no risk factors or extensive cerebrovascular diseases; (5) There are no obvious behavioral and language barriers. 2. For patients whose MOCA score is less than 26, if the education period is less than or equal to 12 years, 1 point will be added on the basis of the score; 3. Patients between 50 and 75 years old; 4. Those who have not regularly carried out various forms of exercise for more than three times a week for at least 20 minutes in the last six months; 5. Subjects with informed consent and voluntary participation. Only those who meet all the above conditions can be included in the study.

Exclusion criteria

Exclusion criteria: 1. Hypertension patients with uncontrollable blood pressure (diastolic blood pressure still exceeds 100mmhg or systolic blood pressure still exceeds 160mmhg); 2. Patients with a history of serious alcohol and drug abuse; 3. Patients with cognitive impairment caused by depression; 4. Patients with cognitive impairment caused by poisoning or drugs; 5. Patients with a history of mental illness (such as personality disorder, schizophrenia, etc.), severe aphasia and audio-visual disorder, or with severe organ failure, musculoskeletal system disease, coronary heart disease, myocardial infarction, musculoskeletal system disease and other contraindications of sports therapy; 6. Subjects who are participating in other clinical trials and will affect the outcome evaluation of this study.

Design outcomes

Primary

MeasureTime frame
MoCA;

Secondary

MeasureTime frame
ADL;NPI;CSDO;MMSE;

Countries

China

Contacts

Public ContactHan Zhenyun

Beijing University of Chinese Medicine Shenzhen Hospital

tohanzhenyun@sina.com+86 13581647676

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026