Vascular dementia
Conditions
Interventions
Sponsors
Shuguang Hospital Affiliated to Shanghai University of TCM
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Right-handed, aged40-80 years, regardless of gender; 2. MRI and / or CT support the existence of ischemic cerebrovascular disease, which accords with the diagnostic criteria of NINDS-AIREN; 3. The education level above primary school (including primary school); 4. Meets the diagnostic criteria of dementia (DSM-IV); 5. Meeting the probable VaD diagnostic criteria of NINDS-AIREN; 6. Modified Hachinski Ischemia scale (MHIS), total score >= 4; 7. Patients with mild or moderate severity: 10 <= MMSE <= 26 and 1 <= CDR <= 2; 8. Hamilton depression scale, HAMD total score of Hamilton Depression scale <= 17; 9. There is no taboo on MRI scanning.
Exclusion criteria
Exclusion criteria: 1. There was memory or other cognitive dysfunction in the past, but no obvious ischemic focus on the image; 2. With cognitive impairment caused by trauma, tumor, infection, thyroid dysfunction, alcoholism, etc; 3. With severe vision, hearing impairment and aphasia, affect the examination or can not cooperate with the dementia scale evaluation or can not cooperate with the head immobilization; 4. With anxiety, depression, mental disorder and disturbance of consciousness; 5. With abnormal laboratory indexes; 6. With severe circulatory, respiratory, urinary, digestive, hematopoietic diseases (such as unstable angina pectoris, uncontrollable asthma, active gastric hemorrhage, etc.) and cancer; 7. Pregnant or lactating women; 8. With history of brain trauma or cerebral hemorrhage within 1 month; 9 With contraindications for MR examination; 10. Taken a acupuncture treatment in the past 4 weeks; 11. Unable to complete the basic course of treatment, poor compliance (that is, unable to adhere to treatment) and difficult to follow up in the future.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE;fractional?anisotropy;mean diffusivity;VaDAS-cog; | — |
Countries
China
Contacts
Public ContactKang Yingjie
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed