Polycystic ovary syndrome with obesity
Conditions
Interventions
Sponsors
Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Inclusion criteria of PCOS 1. Infertile female with the reproductive needs, aged 20 to 40 years; 2. Diagnosed as having PCOS; 3. BMI>=25kg/m2; 4. Suitable for using clomiphene as ovulation induction treatment; 5. Sign the inform consent. Inclusion criteria of health participants: 1. Female, aged 20 to 40 years; 2. BMI<25kg/m2; 3. Regular menstruation; 4. Without primary dysmenorrhea in recent 1 year; 5. Normal blood/stool/urine test and SAS/SDS scales; 6. Sign the inform consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria of PCOS: 1. Not diagnosed as PCOS; 2. Taking antibiotics history within 3 months; 3. Allergic constitution or allergic to various kinds of medicine; 4. Hyperandrogenism due to other reasons, including hyperprolactinemia, thyroid disease, congenital adrenal hyperplasia, Cushing syndrome, etc.; 5. Pathological endometrial changes, such as uterine malformation, hysteromyoma, etc., diagnosed by B ultrasound; 6. Genital tract malformation, gonadal dysgenesis, fallopian tube block, etc.; 7. Severe heart, liver, or renal dysfunction or hematological, respiratory, cardiovascular, psychiatric, or other metabolic disease; 8. Participation in other clinical trials at the same time; 9. Gastrointestinal surgery history; 10. Smoking history, alcohol history, inflammatory bowel disease, irritable bowel syndrome, autoimmune diseases, cancer and other disease that may influence the gut microbiota; 11. Taking probiotics with 1 month; 12. Suffering disease(s) causing inflammation without control; 13. Anxiety and depression; Note: 1 to 8 are suitable for clinical observation. 1 to 13 are suitable for gut microbiota analysis. Exclusion criteria of health participants: 1. Taking antibiotics history within 3 months; 2. Smoking history, alcohol history; 3. Diagnosed as psychosis, anxiety, depression, cognitive disorder, and allergic constitution. 4. Pregnant and breast-feeding woman; 5. Gastrointestinal surgery history; 6. Inflammatory bowel disease, irritable bowel syndrome, autoimmune diseases, cancer and other disease that may influence the gut microbiota; 7. Taking probiotics with 1 month; 8. Suffering disease(s) causing inflammation without control; 9. Participation in other clinical trials at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LH/FSH; | — |
Secondary
| Measure | Time frame |
|---|---|
| liver function and kidney function test;Six sex hormones analysis;Basal Body Temperature, BBT;FBG(fasting blood-glucose);inflammatory marks analysis;SAS anxiety scale;C- peptide release tests;urinary test;SDS depression scale;Intestinal flora analysis;Waist;blood routine examination;Leptin;Serum lipid level;Stool test; | — |
Countries
China
Contacts
Public ContactJiao Chen
Chengdu University of Traditional Chinese Medicine
Outcome results
None listed