Diabetic Kidney Disease
Conditions
Interventions
control group:Placebo
Sponsors
Hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
25 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients were diagnosed Diabetic Kidney Disease meeting the criteria of the 2014 Consensus of Experts on Prevention and Treatment of DKD of Chinese Diabetes Society; 2. Patients aged between 25 and 75 years old; 3. eGFR>=30mL/min/1.73m2 without dialytic treatments; 4. For patients with hypertension, blood pressure<=140/90 mmHg; for the elderly, systolic blood pressure (SBP)<= 150mmHg; 5. Glycosylated hemoglobin (HbA1c) should be less than or equal to 7%; for patients with serious complications such as recurrent hypoglycemia, severe microvascular or macrovascular complications, or it is difficult to meet the standard requirements despite adequate treatment, then HbA1c should be less than or equal to 8%; 6. Patients with ability to read, understand and write research-related materials, and voluntarily comply with all test requirements; 7. Patients voluntarily participate in the study and written the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe infection, anemia, electrolyte imbalance, or acute complications of DM in the previous 4 weeks; 2. Severe cardiac, cerebral, hepatic, or hemorrhagic diseases, including cerebral infarction, cerebral hemorrhage, transient ischemic attack, myocardial infarction, unstable angina, heart failure, and hepatic inadequacy with aspartate transaminase (AST) or alanine aminotransferase (ALT) levels more than 2 twice the normal upper limit; 3. Use of corticosteroids or immunosuppressants in the previous 3 months; 4. Oliguria, anuria, severe edema, massive pleural or peritoneal effusion; 5. Renal transplantation; 6. Mental disorders; 7. Pregnancy or lactation; 8. Allergy to the trial drugs; 9. Participation in other clinical studies; 10. Incomplete understanding of the study, refusal to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24h urinary protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| SCr and eGFR;postprandial 2-hour blood glucose (2hPG);blood lipids (including total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C);TCM syndrome score;urinary albumin excretion rate (UAER);fasting blood glucose (FBG); | — |
Countries
China
Contacts
Public ContactLiao Ting-Ting
Hospital of Chengdu University of Traditional Chinese Medicine
Outcome results
None listed