The efficacy and mechanisms of transcutaneous auricular vagus nerve stimulation on symptom in patients with IBS-C

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ITMCTR

Registry ID

ITMCTR2000002986

Enrollment

Unknown

Registered

2020-02-09

Start date

2020-03-01

Completion date

Unknown

Last updated

2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Constipation-dominant irritable bowel syndrome

Interventions

Group true ta-VNS stimulation:Stimulate bilateral ear shells

Group sham ta-VNS stimulation:Stimulate the lateral ends of the lateral elbow stripes

Eligibility

Sex/Gender

All

Age

17 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Willing to sign informed consent; 2. Aged 18 to 75 years, regardless of gender; 3. Meets IBS-C Rome IV diagnostic criteria.

Exclusion criteria

Exclusion criteria: 1. History of previous abdominal surgery related to IBS-C symptoms (except appendectomy); 2. Currently taking antidepressants, including tricyclic antidepressants and selective serotonin reuptake inhibitors; 3. Use of anticholinergics, antipsychotics or antispasmodics in the past 2 weeks; 4. Currently participating in another trial or in the past month; 5. Currently pregnant or planning to become pregnant; 6. Accompanied by severe heart, liver or kidney disease, or have diabetes; 7. Researchers do not consider it suitable for participants.

Design outcomes

Primary

Measure	Time frame
Visual Analogue Scale;Completely autonomous bowel movements;	—

Secondary

Measure	Time frame
IBS symptom severity score;IBS Quality of Life Questionnaire;	—

Countries

China

Contacts

Public ContactLiu Fei

liufeiguo2010@163.com+86 18621761216

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026