diabetes
Conditions
Interventions
Sponsors
The First Affiliated Hospital, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Subject should have a strong understand of the object, nature and eventuality of trial, volunteer for the trial and sign the informed consent. 2. Aged 18 to 45 years old, both men and women; 3. Male subjects with weight more than 50 kg (contain 50 kg), female subjects with weight more than 45 kg (including 45 kg); 4. Subjects Can communicate well with the researchers and comply with the requirements of the entire study.
Exclusion criteria
Exclusion criteria: 1. According to comprehensive physical examination and laboratory test, the researchers were not identified as healthy subjects; 2. Any medical history of cardiovascular, hepatic, kidney, gastrointestinal tract, and respiratory, metabolic, nervous system, (especially the spastic diseases such as epilepsy), chronic infectious and other major diseases; 3. Allergic constitution: the persons allergic to two or more medicines, food and pollen or rehmannia; 4. History of hypoglycemia; 5. Drug abusenicotine or alcohol test positive; 6. Faint at the sight of blood or needle; 7. Blood donation or a history of acute blood loss (more than 400 mL) in 3 month of the study; 8. Participating in other clinical trials within the past 3 months; 9. Subject took over 5 cigarettes or Equivalent amounts of tobacco products every day in the past 3 months. 10. Drug abuse history in past 5 years or had ever used drugs inpast 3 months before screening. 11. Within 2 years prior to screening has a history of alcohol abuse, that drinking more than 3 units of 12. Alcohol of a day and 21 units of alcohol a week (1 = 350 mL beer, 120 mL liqueur, 30mL alcohol or 150 mL wine) ; 13. Pregnant or nursing women; Fertile woman cannot take effective appropriate precautions in 3 months after the study; 14. Subjects with acute disease during screening period; 15. Used any medicine in the last 2 weeks; 16. Female subjects did not take non-drug contraceptive measures within 14 days before enrollment; 17. Unsuitable to participate in the trial considered by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MTD;AUC0-t;Cmax;Adverse events; | — |
Countries
China
Contacts
Public ContactShentu Jianzhong
Outcome results
None listed