Chronic migraine
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Meet the ichd-3beta diagnostic criteria issued by the international headache society (IHS) in 2018; 2. CT or MRI of the skull was normal, with neurologic examination (-); 3. Aged 18-55 years; 4. Those who are aware of the study and voluntarily sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with otogenic vertigo, cervical vertigo, vertigo epilepsy, multiple sclerosis, stroke, cardiovascular disease, diabetes, obesity and other metabolic disorders; 2. Patients with recent infection and other inflammatory reactions; 3. Patients who have taken traditional Chinese medicine for pain relief or proprietary Chinese medicine for nearly 2 weeks, those who have taken short-acting painkillers (except traditional Chinese medicine and proprietary Chinese medicine) for less than 5 half-lives, and those who have taken vitamin B supplements for nearly 1 month; 4. Patients with other organic diseases and tumors; Patients with diet and malnutrition and perinatal women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VEGF;CGRP;Liver function;NO;DIC;SP;The pupil parameters;5-HT;6/5000 Common carotid artery diameter;Renal function;Diffusion tensor NMR imaging;Electrocardiogram, ECG;Ang;Routine blood;ET-1; | — |
Countries
China